Investigating Distinct and Overlapping Mechanisms in TDP-43 Proteinopathies, including in LATE, FTD and other ADRDs (R01 - Clinical Trial Not Allowed)

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Key Information

Due Date: October 4, 2024


Agency: U.S. Department of Health and Human Services (HHS)


Source: Federal


Funding Category:

Health & Human Services

Funding Amount: $500,000


Funding Type: Grant, Government


Match Required: No


Contact Info: grantsinfo@nih.gov
See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

Overview

This grant, labelled as R01, is called "Investigating Distinct and Overlapping Mechanisms in TDP-43 Proteinopathies, including in LATE, FTD and other ADRDs", and does not fund any clinical trial. This Funding Opportunity Announcement (FOA) aims to support research that seeks to understand TDP-43 proteinopathies better.

To be specific, the focus lies on unveiling a deeper understanding of the mechanisms behind TDP-43 pathology and the outcomes this proteinopathy presents in patients, aiming to figure out causal relationships. Another critical area the grant supports is the exploration of how TDP-43 interacts with other co-pathologies, such as TMEM106B.

Furthermore, the grant encourages comparative studies between different TDP-43 proteinopathies, such as LATE, with or without AD-NC, and diseases like FTD and/or ALS. The comparisons could span various research areas such as mechanisms, molecular and cellular structures, genetic variations, '-omic' research methods, anatomical correlations, neuropathological differences, and other relevant aspects.

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Key Dates

Open Date: February 6, 2024


Application Due Date: October 4, 2024


Estimated Award Date: Not Specified

Additional Details

Eligible Activities

  • Research and Development

Eligible Applicants

  • State governments
  • County governments
  • City, village or township governments
  • Special district governments
  • Independent school districts
  • Public and State controlled institutions of higher education
  • Native American tribal governments(Federally recognized)
  • Public housing authorities/ Indian housing authorities
  • Native American tribal organizations(other than Federally recognized tribal governments)
  • Nonprofits having a 501(c)(3) status with the IRS
  • other than institutions of higher education
  • Nonprofits that do not have a 501(c)(3) status with the IRS
  • Private institutions of higher education
  • For-profit organizations other than small businesses
  • Small businesses
  • Others

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