Investigating Distinct and Overlapping Mechanisms in TDP-43 Proteinopathies, including in LATE, FTD and other ADRDs (R01 - Clinical Trial Not Allowed)

This grant, labelled as R01, is called "Investigating Distinct and Overlapping Mechanisms in TDP-43 Proteinopathies, including in LATE, FTD and other ADRDs", and does not fund any clinical trial. This Funding Opportunity Announcement (FOA) aims to support research that seeks to understand TDP-43 proteinopathies better.

To be specific, the focus lies on unveiling a deeper understanding of the mechanisms behind TDP-43 pathology and the outcomes this proteinopathy presents in patients, aiming to figure out causal relationships. Another critical area the grant supports is the exploration of how TDP-43 interacts with other co-pathologies, such as TMEM106B.

Furthermore, the grant encourages comparative studies between different TDP-43 proteinopathies, such as LATE, with or without AD-NC, and diseases like FTD and/or ALS. The comparisons could span various research areas such as mechanisms, molecular and cellular structures, genetic variations, '-omic' research methods, anatomical correlations, neuropathological differences, and other relevant aspects.