Limited Competition: Specific Pathogen Free Macaque Colonies to Support HIV/AIDS Research (U42 Clinical Trial Not Allowed)

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Key Information

Due Date: January 7, 2027


Agency: U.S. Department of Health and Human Services (HHS)


Source: Federal


Funding Category:

Health & Human Services

Funding Amount: Not Specified


Funding Type: Cooperative Agreement


Match Required: No


Contact Info: grantsinfo@nih.gov
See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

Overview

This grant is a Limited Competition, focusing on Specific Pathogen Free (SPF) Macaque Colonies that assist HIV/AIDS Research. It does not support Clinical Trials (U42). This Notice of Funding Opportunity (NOFO) aims to continue supporting SPF macaque colonies that were initially funded under PAR-21-089 and PAR-18-669, to contribute to HIV/AIDS research.

The funding is particularly critical for breeding colonies in sustaining an optimal stock of SPF macaques necessary for AIDS/HIV research. SPF macaques, also known as the Pedigree SPF macaques, are free of certain types of viruses. This letter is essential since the presence of these viruses could either distort the outcomes of HIV/AIDS studies or create a risk scenario for the staff who handle these animals.

The SPF macaques also undergo a detailed analysis of their genetic structure, with a particular focus on the major histocompatibility complex (MHC) class I types. This scrutiny is because the MHC class 1 genotypes can substantially affect macaque immune responses to Simian Immunodeficiency Virus (SIV) that can trigger AIDS in nonhuman primates (NHPs). These genotypes also affect human immune responses to HIV. Therefore, the grant is substantially aiding the research for HIV/AIDS.

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Key Dates

Open Date: January 22, 2024


Application Due Date: January 7, 2027


Estimated Award Date: Not Specified

Additional Details

Eligible Activities

  • Research and Development

Eligible Applicants

  • Public and State controlled institutions of higher education

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