Targeting Inflammasomes in HIV and Substance Use (R01 Clinical Trial Not Allowed)

This grant, titled "Targeting Inflammasomes in HIV and Substance Use (R01 Clinical Trial Not Allowed)", is offering financial support for scientific research. The main aim of the research should be to examine the role of inflammasomes - complexes within a cell that are associated with inflammation - in the nerve damage caused by either acute or chronic drug use and HIV infection. The study of inflammasomes in relation to virus and drug-induced immune responses could help to recognise the molecular indicators and immune cells within the central nervous system that are associated with HIV-1 infection or disease progression in individuals who abuse substances. Furthermore, this research could help discover new potential treatments by focusing on either stimulating or suppressing inflammasome activation as a method for treating nerve inflammation and irregular immune responses that are triggered by these processes.