Translational Research Toward Development of a Kaposi Sarcoma Herpesvirus (KSHV) Vaccine (U01 Clinical Trial Optional)

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Key Information

Due Date: December 4, 2024


Agency: U.S. Department of Health and Human Services (HHS)


Source: Federal


Funding Category:

Health & Human Services

Funding Amount: Not Specified


Funding Type: Cooperative Agreement


Match Required: No


Contact Info: grantsinfo@nih.gov
See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

Overview

The National Cancer Institute (NCI) is making an announcement for a new funding opportunity geared towards the development of a Kaposi Sarcoma Herpesvirus (KSHV) vaccine, both prophylactic and therapeutic in nature. This builds on existing research related to the transmission of KSHV conducted under previous funding opportunities.

A prophylactic vaccine would aim to prevent initial KSHV infection and its transmission, potentially reducing the chances of developing Kaposi Sarcoma and other associated conditions like multicentric Castleman disease, primary effusion lymphoma, and KSHV inflammatory cytokine syndrome, or lessening the disease severity. On the other hand, a therapeutic vaccine would target people already infected with KSHV, seeking to prevent or treat the disease.

The scope of research supported by this funding would cover various areas. These may include identifying and evaluating potential KSHV vaccine targets, the creation of animal models for testing vaccines, development and testing of potential KSHV vaccines, and studies meant to improve the efficiency of an effective KSHV vaccine in people with HIV.

In addition, the research would aim to understand the early steps of KSHV infection and primary means of transmission between people within different populations for better vaccine targeting. The grant would also support work on optimizing and standardizing methods for detecting KSHV.

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Key Dates

Open Date: October 16, 2023


Application Due Date: December 4, 2024


Estimated Award Date: Not Specified

Additional Details

Eligible Activities

  • Research and Development

Eligible Applicants

  • State governments
  • County governments
  • City, village or township governments
  • Special district governments
  • Independent school districts
  • Public and State controlled institutions of higher education
  • Private institutions of higher education
  • Small businesses

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