Mechanistic Research on Neuromodulation for Substance Use Disorders Treatment (R61/R33 Basic Experimental Studies with Humans Required)

The Mechanistic Research on Neuromodulation for Substance Use Disorders Treatment fund is a grant opportunity that seeks to stimulate innovation in clinical research. It specifically encourages research into novel targets for non-invasive brain stimulation (NIBS), along with assessing the responses of neurobiological, cognitive, and behavioral aspects to NIBS in the context of substance use disorders (SUD). The ultimate aim of such projects would be to reduce drug cravings or usage.

Applicants can propose exploratory and developmental studies that, despite their potential failure risk, could potentially lead to significant breakthroughs in the field of SUD research related to NIBS. The grant supports the R61/R33 Phased Innovation award activity code, which focuses on mechanistic studies. These studies explore an intervention's mechanism of action, biological processes, or disease pathophysiology.

All applications need to adhere to the National Institutes of Health's (NIH) definition of a clinical trial. The NIH defines a clinical trial as a research study that prospectively assigns human subjects to one or more interventions, including controls or placebos. The aim is to evaluate the impact of these interventions on health-related biomedical or behavioral outcomes.