Developing novel theory and methods for understanding the genetic architecture of complex human traits (R01 Clinical Trial Not Allowed)

The provided information outlines a Notice of Funding Opportunity (NOFO) intending to sponsor R01 applications. The primary aim of these applications should be to develop new theories and methods to enrich our understanding of the genetic structure of complicated human traits.

This goal requires research that helps define how both genetic and non-genetic aspects cause variances in intricate traits among individuals, families, and even entire populations. This study should adopt an interdisciplinary approach, integrating tools and perspectives from both natural and social sciences.

Moreover, the research should also account for interdependencies across varying levels of biological, social, and ecological organization to provide a more comprehensive understanding of the topic. Making substantial usage of theories and simulations is required, along with verifying these methodologies by utilizing accessible large-scale datasets. Importantly, this grant does not cater to clinical trials.