Mechanistic Research on Neuromodulation for Substance Use Disorders Treatment (R61/R33 Clinical Trial Optional)

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Key Information

Due Date: August 14, 2026


Agency: U.S. Department of Health and Human Services (HHS)


Source: Federal


Funding Category:

Health & Human Services

Funding Amount: Not Specified


Funding Type: Grant, Government


Match Required: No


Contact Info: grantsinfo@nih.gov
See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

Overview

This grant, known as the Mechanistic Research on Neuromodulation for Substance Use Disorders Treatment (R61/R33 Clinical Trial Optional), aims to foster clinical research to discover and validate potential targets for non-invasive brain stimulation (NIBS). This stimulation would help in understanding SUD-related neurobiological, cognitive, and behavioral responses. The ultimate goal of this research is to find ways to reduce substance craving or overall drug use.

The grant is designed to support exploratory and developmental studies. These projects may be risky and might not result in immediate success. However, it's hoped that they may lead to significant progress or breakthroughs in using non-invasive brain stimulation (NIBS) for substance use disorder (SUD) research.

Grant recipients will be using R61/R33 Phased Innovation award activity codes to plan their mechanistic studies. These studies will aim to increase our understanding of a certain behavior or biological process, a disease's pathophysiology, or how a particular intervention works.

To qualify for this grant, all applications must fit the National Institutes of Health's (NIH) definition of a clinical trial. According to the NIH, a clinical trial is a research study where human subjects are assigned to one or more interventions (including placebo or other control). This assignment is aimed at evaluating the effects of the interventions on health-related biomedical or behavioral outcomes. (NOT-OD-15-015).

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Key Dates

Open Date: September 29, 2023


Application Due Date: August 14, 2026


Estimated Award Date: Not Specified

Additional Details

Eligible Activities

  • Research and Development

Eligible Applicants

  • State governments
  • County governments
  • City, village or township governments
  • Special district governments
  • Independent school districts
  • Public and State controlled institutions of higher education
  • Private institutions of higher education
  • Small businesses

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