Advancing Research to Understand Congenital Malformations (R01 Clinical Trial Not Allowed)

The Advancing Research to Understand Congenital Malformations grant program is a funding opportunity aimed at supporting innovative research to better comprehend the mechanisms behind structural birth defects. It's noteworthy that this funding does not allow for clinical trials. Researchers are encouraged to use animal models alongside human translational/clinical approaches for this research.

A highlighted aspect of this program is the encouragement for applicants to utilize advanced scientific methodologies. It invites applications which harness the power of genetics, omics methods that include genomics, proteomics, metabolomics and so on, as well as synthetic biology. This also includes biochemical approaches and other methodologies applicable to developmental biology research.

The grant program is looking for projects that can identify specific genetic and epigenetic factors, environmental influences, or their interactions which are associated with formation of structural birth defects. Furthermore, the program looks for research tackling the variability and susceptibility to these defects across different human populations.