Integrative Research to Understand the Impact of Sex Differences on the Molecular Determinants of AD Risk and Responsiveness to Treatment (U01 Clinical Trial Optional)

This Funding Opportunity Announcement (FOA) is a call for applications that focus on researching sex differences' impact on Alzheimer's Disease (AD) and AD-related dementias (ADRD). The focus lies on holistic research that examines both basic and clinical/translational science to deeply understand the role of sex differences in brain aging trajectories, AD and ADRD risk phenotypes, individual preventive measures, and responsiveness to various treatment methods, including pharmacologic and non-pharmacologic interventions.

The primary objective of this initiative is to establish robust research programs to explore the interplay of various factors leading to diverse disease risk phenotypes and responses to prevention or therapy in AD and ADRD. These factors include genes, environmental factors, and host-specific facets such as hormonal status, both gonadal and brain-derived. The research should scrutinize these interactions at varying levels of biological complexity - cell, tissue, organs/organ systems, and population.

The project's title is 'Integrative Research to Understand the Impact of Sex Differences on the Molecular Determinants of AD Risk and Responsiveness to Treatment,' and it provides an opportunity for a clinical trial.