Microbial-based Cancer Imaging and Therapy - Bugs as Drugs (R21 Clinical Trial Not Allowed)

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Key Information

Due Date: May 7, 2025


Agency: U.S. Department of Health and Human Services (HHS)


Source: Federal


Funding Category:

Health & Human Services

Funding Amount: $581,371


Funding Type: Grant


Match Required: No


Contact Info: OERWebmaster03@od.nih.gov
See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

Overview

The "Microbial-based Cancer Imaging and Therapy - Bugs as Drugs" scheme is a Funding Opportunity Announcement (FOA) that invites grant applications for research into using bacteria and non-oncolytic viruses for cancer diagnostics and treatment. The aim is to study the complex interactions between microorganisms, tumors, and the immune system.

The projects can concentrate on using microorganisms as anti-tumor agents, initiators of anti-tumor immunity, or as carriers for delivering treatment, imaging, or diagnosis. They also have the potential to complement or synergize with existing cancer treatment tools and methods.

Financial help will be provided for basic mechanistic and preliminary studies in cell cultures and animal models. Applicants are encouraged to analyze both microbial activities and tumor response in relation to microbial-based cancer therapy, including oral cancer treatments, as well as tumor detection, imaging, or diagnostics.

The R21 FOA is designed to stimulate the exploration of projects in their early conceptual stages or feasibility studies, from inception through initial development, in order to display the core functional abilities of the proposed method. These projects can entail substantial risk, but the objective is to generate breakthroughs in microbial-based cancer therapy, imaging, or diagnostic techniques.

This funding opportunity forms part of a wider program of research sponsored by the National Cancer Institute (NCI) on microbial-based cancer therapy.

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Key Dates

Open Date: February 18, 2022


Application Due Date: May 7, 2025


Estimated Award Date: Not Specified

Additional Details

Eligible Activities

  • Research and Development

Eligible Applicants

  • State governments
  • County governments
  • City, village or township governments
  • Special district governments
  • Independent school districts
  • Public and State controlled institutions of higher education
  • Private institutions of higher education
  • Small businesses

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