Modulating Human Microbiome Function to Enhance Immune Responses Against Cancer (R01 Clinical Trial Not Allowed)

This grant, titled "Modulating Human Microbiome Function to Enhance Immune Responses Against Cancer (R01 Clinical Trial Not Allowed)", is focused on supporting fundamental research aimed at understanding the role of the human microbiome in enhancing or inhibiting anti-cancer immune responses. The goal of the research sponsored by this grant is to uncover new molecular targets that could be used in cancer prevention strategies.

Applications for this grant should center on investigating how interactions between the host and specific microbes (or groups of microbes), or their metabolites, affect immune responses. These responses should either enhance or prevent the formation of tumors, whether associated with inflammation or sporadic in nature.

Proposed studies should also closely examine how the effectiveness of beneficial microbes can be influenced by the concentration, timing, and duration of administration. Applicants should rigorously address these parameters in their applications to ensure optimum results. Researchers are encouraged to apply if they are interested in exploring these interactions and impacts, with a focus on achieving potential breakthroughs in cancer prevention.