Neuromodulation/Neurostimulation Device Development for Mental Health Applications (R21 Clinical Trial Not Allowed)

This is a grant offered for the development of Neuromodulation/Neurostimulation devices, specifically designed for mental health applications. It's a reissue of the previous grant known as PAR-18-941. The grant's main goal is to encourage researchers and developers to create innovative brain stimulation devices aimed at treating mental health disorders.

The grant is open for applications focusing on two areas. The first is ideating and developing absolutely new devices for brain stimulation. The second area is centered on enhancing the effectiveness of existing brain stimulation devices approved by the U.S. Food and Drug Administration (FDA). These enhancements can be achieved by making significant improvements to the device's hardware or software.

For those seeking to create innovative devices, the focus should be on developing advanced stimulation techniques that surpass current electrical/magnetic stimulation models. These new methods should have better spatiotemporal precision and incorporate multi-focal, closed-loop approaches.

If the goal is to enhance current capabilities, the improvements should significantly increase the device's spatial resolution, depth of delivery, and precision. It's important to clarify that minor changes like software updates aren't considered significant enhancement under this grant.

Applications should be submitted by multidisciplinary teams. Ideally, these teams should possess a variety of skills and expertise in systems neuroscience, engineering, clinical practices, and regulatory affairs to be considered for this grant.