Screening and Functional Validation of Human Birth Defects Genomic Variants (R01 Clinical Trial Not Allowed)
Key Information
Due Date: May 7, 2025
Agency: U.S. Department of Health and Human Services (HHS)
Source: Federal
Funding Category:
Health & Human Services
Funding Amount: $581,371
Funding Type: Grant
Match Required: No
Status: Posted
Contact Info:
grantsinfo@nih.gov
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Overview
There is a wealth of genomic data available on pediatric birth defects populations, sourced from several databases like The Database of Genotypes and Phenotypes, The Gabriella Miller Kids First Data Resource Portal, the European Genome-Phenome Archive, and Clinical Genome Resource. This data will serve to be highly instrumental for researchers involved in the study.
The essence of this initiative is to foster the screening, functional validation, and characterization of genetic variants linked to birth defects using publicly accessible databases and individual attempts. Various methods such as in-silico tools, appropriate animal models, in vitro systems, or multi-pronged approaches can be employed for this purpose.
The initiative aims to bridge the challenging gap between the identification of potentially interesting sequence variations and understanding which of these variations have functional impacts on the phenotype of concern. Note that this project does not involve conducting any clinical trial.
Key Dates
Open Date: May 5, 2021
Application Due Date: May 7, 2025
Estimated Award Date: Not Specified
Additional Details
Eligible Activities
- Research and Development
Eligible Applicants
- State governments
- County governments
- City, village or township governments
- Special district governments
- Independent school districts
- Public and State controlled institutions of higher education
- Private institutions of higher education
- Small businesses