Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required)

The Research Project Grant or Parent R01 is an initiative supported by the National Institutes of Health (NIH). It is specifically designed to provide funding for a distinct and clearly outlined research project that falls within the field of interest and expertise of the applying researcher or team.

This particular grant announcement is aimed at basic science experimental studies which involve human participants, also known as prospective basic science studies. These projects come under the NIH’s definition of a clinical trial and basic research.

The studies appropriate for this funding opportunity are those that purposefully assign human participants to different conditions for experimental purposes, such as to manipulate independent variables. The outcomes measured in these studies should be related to biomedical or behavioral aspects. The ultimate goal of these studies is to expand our understanding of basic phenomena, and they should not be conducted with a specific application or product in mind.

For studies that have a specific application or product in mind, there are different funding opportunities available, such as the Clinical Trials Required or Clinical Trial Optional funding announcements.

To become eligible for the Parent R01 grant, the proposed project must align with the programmatic interests of one or more NIH Institutes and Centers (ICs), based on their particular scientific missions.