Neural Ensembles & Used Substances (Nexus) Collaboratory: Building a Multimodal Inventory of Cell Ensembles Encoding the Effects of Addictive Substances (U01 Clinical Trial Not Allowed)

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Key Information

Due Date: February 8, 2027


Agency: United States Department of Health and Human Services


Source: Federal


Website: View Website


Funding Categories:

Funding Amount: $4,000,000


Funding Type: Cooperative Agreement


Match Required: No


Status: Posted


Contact Info: INBranch_NIDA@nih.gov
Integrative Neuroscience Branch Program Staff INBranch_NIDA@nih.gov

Overview

The National Institute on Drug Abuse (NIDA) invites applications to renew and expand the Collaboratory on Neural Ensembles and Used Substances (NExUS).

NExUS is a collaborative research program to decode how substance use experiences and addictive neurobehavioral states are represented in the brain at the level of cell populations.

This funding opportunity seeks applications that propose systematic and scalable methods to identify, map, and analyze groups of neurons that respond to used substances. The goal is to create a comprehensive, multimodal database and use it to test hypotheses about how specific neural population activity patterns relate to behavioral states associated with substance use and substance use disorders (SUD), including intoxication, craving, and dependence.

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Additional Info

Posted Date: October 9, 2026


Application Due Date: February 8, 2027


Estimated Award Date: Not Specified


Eligible Applicants:

  • Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
  • City or township governments
  • Public housing authorities/Indian housing authorities
  • Small businesses
  • Public and State controlled institutions of higher education
  • Special district governments
  • Private institutions of higher education
  • State governments
  • County governments
  • Others
  • Independent school districts
  • Native American tribal governments (Federally recognized)
  • Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
  • For profit organizations other than small businesses
  • Native American tribal organizations (other than Federally recognized tribal governments)
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