Molecular, Neural, and Cognitive Mechanisms of Non-Invasive Brain Stimulation to Treat Substance Use Disorders

The National Institute on Drug Abuse (NIDA) intends to publish a Notice of Funding Opportunity (NOFO) to encourage basic research on Non-Invasive Brain Stimulation (NIBS) using animal and human models. NIBS techniques transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), and transcranial focused ultrasound (tFUS) have emerged as promising approaches to treat addiction and substance use disorders (SUDs); however, their mechanisms of action are unclear. This initiative is to support research to (1) elucidate molecular, cellular, and circuit level changes induced by NIBS protocols (2) identify molecular mechanisms and pathways by which NIBS techniques and protocols produce their therapeutic effects in SUDs,(3) identify novel clinical targets for NIBS, and (4) investigate SUD-relevant neurobiological, cognitive, and behavioral responses to NIBS that may precede clinical outcomes. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigators with expertise and insights into neuromodulation by non-invasive brain stimulation are encouraged to apply. In addition, collaborative investigations combining expertise in non-invasive brain stimulation and substance use and addiction are encouraged.